Various bacterial protein toxins and effectors target the actin cytoskeleton. Members of this group are numerous binary actin-ADP-ribosylating exotoxins e. Clostridium botulinum C2 toxin as well as several bacterial ADP-ribosyltransferases e. Salmonella enterica SpvB which are not binary in structure. The second group includes toxins that modify actin to promote actin polymerization and the formation of actin aggregates. To this group belongs a toxin from the Photorhabdus luminescens Tc toxin complex that ADP-ribosylates actin at threonine
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Actin as Target for Modification by Bacterial Protein Toxins
Allgemeine Und Spezielle Pharmakologie Und Toxikologie