ANGIOFIBROMA NASAL JUVENIL PDF

Devido a isto, foi dispensado o Termo de Consentimento Livre e Esclarecido. Resultado este semelhante aos da literatura 15, Dados estes concordantes, portanto, com os da literatura , Eur Arch Otorhinolayngol. Juvenile angiofibroma: a review of the literature and a case series report. Angiofibroma: a rare case in na elderly female.

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Nasopharyngeal angiofibroma: our experience and literature review. Service chief medical residency in Otorhinolaryngology, Universidade Federal de Sergipe. Mailing address. It shows very aggressive behavior due to local invasiveness and is associated with various symptoms. Juvenile nasopharyngeal angiofibroma originates in the sphenopalatine forame, causing epistaxes and nasal obstruction.

Factors analyzed include patient age and gender, symptoms, stages, treatment, length of surgery, intraoperatory bleeding, postoperative need for nasal tampons, hospitalization time, complications, and tumor recurrence. All patients were treated surgically, including 17 who underwent endoscopic surgery. The mean operation time was min, and the mean bleeding volume was mL.

Seventeen patients required clamping of the external carotids and tumor embolization. Keywords: angiofibroma, embolization, therapeutic, epistaxis. Nasopharyngeal angiofibroma is a histologically and biologically benign tumor with aggressive behavior due to its location and associated symptoms including significant epistaxis and nasal obstruction These tumors occur almost exclusively in male adolescents and account for 0.

The tumors are frequently located in the posterolateral wall of the nasal cavity, where the sphenoid process of the palatine bone articulates with the base of the pterygoid process, forming the sphenopalatine foramen.

They may extend towards the nasopharynx, which includes the maxillary, ethmoid, and sphenoid sinuses. Laterally, these tumors may extend to and fill the pterygomaxillary fossa, causing the posterior wall of the maxillary sinus to bulge and eroding the pterygoid plate.

Tumors that further extend into the infratemporal fossa may progress into the orbit, through the inferior orbital fissure and to the base of the skull through the base of the pterygoid process. From a triangular region formed by the foramen ovale, a round and lacerated tumor may reach the middle fossa, migrating to the parasellar region and remaining generally extradual and lateral to the cavernous sinus.

Tumors may invade the anterior fossa through the ethmoid and sphenoid sinuses, being more frequent in the middle fossa and remaining extradural 8,9, The classic triad of epistaxis, unilateral nasal obstruction, and a mass in the nasopharynx suggests a diagnosis of nasopharyngeal angiofibroma and is supplemented by imaging 11,12,13,14, A biopsy is recommended only in cases of diagnostic uncertainty4. Examinations such as computed tomography, nuclear magnetic resonance and even nasal endoscopy can clearly establish the extent of the tumor, its pattern of spread, and consequently, surgical planning 10,11,12,16,17,18, These tests have led to the formulations of multiple classification methods, including the Fisch , Radkowski , Andrews , Bremer , and Antonelli methods 1,4,5,7,8.

These classifications are very important in helping surgeons decide the appropriate surgical approach. Classification of Fisch. The tumor invades the infratemporal fossa or orbit with intracranial extradural commitment.

Non-surgical treatments are available, including the use of hormones estrogen, testosterone , radiation therapy, chemotherapy, and recently, embolization; however, surgery is considered the treatment of choice, with the route depending on the stage of the tumor and the overall condition of the patient 11,12, Vascularization arises most frequently from the maxillary artery i. Surgical approaches for conventional techniques include transpalatal, transmaxillary, lateral rhinotomy, mid-facial degloving, extended sublabial Denker, and Le Fort type I osteotomy 11,13,20, The development of minimally invasive techniques has led to the increased use of endoscopic surgery for the treatment of nasopharyngeal angiofibroma 21 , making it ideal for tumors confined to the nasopharynx, nasal cavity, and sphenoid sinus with minimal extension into the pterygopalatine fossa 10,12,13,15,18, The first description of an endoscopic resection was published in Since then, several cases have been reported, all showing that endoscopic resection resulted in lower morbidity during the early stages of disease In this study, we have described our experience in treating 20 patients with nasopharyngeal angiofibromas in the Department of Otorhinolaryngology.

We analyzed 20 patients with nasopharyngeal angiofibroma who underwent surgery in the otolaryngology service between and Variables analyzed included patient age, sex, symptoms, tumor stage, treatment, duration of surgery, volume of intraoperative bleeding, need for nasal packing after surgery, length of hospitalization, immediate and late complications, recurrence, and preoperative embolization and clamping of the external carotid during surgery.

All patients were classified radiologically and surgically according to the Fisch system. All patients were male, and all had symptoms of progressive nasal obstruction and recurrent epistaxis. Surgical methods in all patients were based on Fisch classifications. Of the 20 patients, 3 had surgery by combined approaches conventional and endoscopic , including 1 patient with a Fisch IIIA tumor who was treated by the Caldwell-Luc expanded technique and endoscopic surgery, 1 patient with a Fisch IIIA tumor who was treated by the degloving mid-facial technique and endoscopic surgery, and 1 with a Fisch IV tumor who was treated by the degloving mid-facial technique associated with craniotomy and endoscopic surgery.

The other 17 patients underwent endoscopic surgery alone. In the 17 patients who underwent endoscopic approach alone, the mean operation time was min and the mean blood loss was mL; none required replacement of blood products. None of these patients required postoperative nasal packing, and all were discharged the day after surgery. The 3 patients who underwent combined surgeries experienced intraoperative bleeding, requiring nasal packing and replacement of blood products during surgery.

All 20 patients were available for follow-up maximum, 7 years , with none showing evidence of tumor recurrence. The first patient who underwent surgery in our department had a Fisch I tumor, but did not undergo embolization or clamping of the external carotid arteries.

The second patient, also with a Fisch I tumor, underwent clamping of the external carotid arteries without embolization. The third patient with a Fisch I tumor underwent surgery with embolization, but without clamping of the external carotid arteries. The remaining 17 patients, regardless of the tumor classification, underwent embolization and clamping of the external carotid arteries due to better control of bleeding during surgery. Juvenile nasopharyngeal angiofibromas present almost exclusively in men aged years Similarly, our patients ranged in age from 10 to 29 years, with a mean age of 16 years, and all were male.

Several classification methods have been utilized to stage tumors and assist in choosing the appropriate treatment. These classification systems are based on examination methods, including CT, MRI, and endoscopy, and have been utilized to establish the extent of the tumor, its pattern of spread, and consequently, surgical planning 10,11,12,16,17,18, Our patients were classified using the Fisch system, the most widely used in most studies Figures 2 and 3.

Several surgical approaches have been utilized for the removal of nasopharyngeal angiofibromas, including transnasal, transpalatal, transzygomatic, and transcervical accesses, in addition to lateral rhinotomy and mid-facial degloving, with or without extension to the upper lip or concomitant craniotomy 9. The combination of different accesses to the tumor can be required 9.

Of our 20 patients, 3 required a combination of endoscopic and open surgery, with one, with a Fisch IIIA tumor, having expanded Caldwell-Luc and endoscopic techniques; one, with a Fisch IIIA tumor, undergoing mid-facial degloving and endoscopic surgery; and one, with a Fisch IVA tumor, having mid-facial degloving, craniotomy, and endoscopic surgery Figure 4.

The other 17 patients required only endoscopic surgery. Longer duration of surgery is associated with greater changes in body homeostasis due to surgical trauma. Improvements in surgical techniques are designed to shorten surgical time and thereby reduce patient morbidity. Endoscopic surgery is less invasive than open surgery, causing less damage to the patient. Consistent with previous results, we found that the mean operation time in the 17 patients who underwent endoscopic surgery alone was min Moreover, the mean blood loss in these patients was mL.

This relatively low blood loss may be due to the use of surgical endoscopy, providing better control of bleeding than open surgery, with or without endoscopy. Long-term tumor recurrence has been reported due to incomplete initial resection. For example, a retrospective study of 15 patients found tumor recurrence in 1 patient 6. The recurrence rate of endoscopically resected tumors has been shown to be low, and we found that none of our 20 patients experienced tumor recurrence.

This may have been due to their relatively early diagnosis, when tumors are found smaller and easier to remove completely, as well as due to the use of endoscopic surgery, which assists in controlling tumor removal, including more accurate examinations of the spaces previously occupied by the tumor.

Many studies highlight the benefit of preoperative arterial embolization to control bleeding intraoperative 16,29, Studies comparing surgical treatment with or without embolization have shown that preoperative embolization reduced intraoperative blood loss and the need for replacement of blood products 31, Blood loss, which was mL in a non-embolized patient, was reduced to mL in embolized patients Ideally, the time between the completion of embolization and the endoscopic procedure should be as small as possible, approximately h Of our 20 patients, only 2 underwent surgery without embolization, with these 2 showing significantly greater intraoperative bleeding than the 18 patients who underwent embolization.

Tumor size was not associated with bleeding. The 18 patients who underwent embolization did so h prior to surgery Figure 5. Some surgeons, however, do not routinely perform embolization preoperatively, finding that embolization is justified only in larger tumors The volume of intraoperative bleeding has been shown to be similar in patients with and without embolization 34 , whereas tendency to relapse was greater in patients undergoing embolization. In addition, preoperative embolization may complicate the identification of the full extent of surgical margins by reducing the tumor size and increasing the risk of relapse None of our patients experienced complications due to embolization.

However, as in any invasive procedure, embolization presents risks that should be fully explained to the patients The most significant risk is blindness, for patients with occlusion of the ophthalmic or middle cerebral artery through the collateral circulation. To minimize complications, surgery should be performed at centers with extensive experience. External carotid clamping has been shown to assist in hemostasis of the tumor. Intraoperative control of bleeding during the resection of nasopharyngeal angiofibromas can be achieved successfully by temporary clamping of the external carotid arteries in the neck Of our 20 patients, only 2 underwent surgery without clamping of the external carotid arteries, with both showing more bleeding than the 18 who underwent surgery with clamping.

Tumor volume was not associated with bleeding in patients with and without clamping. We also found that patients who underwent clamping of the external carotid artery and embolization showed less intraoperative bleeding than patients who underwent embolization alone. Patients undergoing embolization require external carotid clamping due to collateral circulation, which can increase bleeding. Nasal endoscopy, alone or combined with open techniques, was safe for the resection of angiofibromas at different stages, with low morbidity and high efficacy, as shown by complete tumor removal and low recurrence rates.

Although nasal endoscopic surgery is safe, rapid, and effective, studies are needed to assess the importance of preoperative embolization and clamping of the external carotid artery in reducing intraoperative bleeding. Gaeta MM. Nasoangiofibroma juvenil frecuencia. Intracranial juvenile nasopharyngeal angiofibroma. Clin Oncol. Sanchez de Guzman G. Arch Otolaryngol Head Neck Surg. Sociedade Brasileira de Otorrinolaringologia. Tratado de otorrinolaringologia. Definitive Radiotherapy for Juvenile Nasopharyngeal Angiofibroma.

Am J Clin Oncol. Braz J Otorhinolaryngol.

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Juvenile nasopharyngeal angiofibroma

Nasopharyngeal angiofibroma is a histologically benign but locally aggressive vascular tumor of the nasopharynx that arises from the superior margin of the sphenopalatine foramen and grows in the back of the nasal cavity. It most commonly affects adolescent males because it is a hormone-sensitive tumor. Though it is a benign tumor, it is locally invasive and can invade the nose, cheek, orbit frog face deformity , or brain. If nasopharyngeal angiofibroma is suspected based on physical examination a smooth vascular submucosal mass in the posterior nasal cavity of an adolescent male , imaging studies such as CT or MRI should be performed.

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Nasopharyngeal angiofibroma

Juvenile nasopharyngeal angiofibroma: a case presentation. Sergio J. Pinar del Rio. It was observed a nasal obstruction with 2 years of evolution being associated to light epitasis in the last months as well as rhinolalia, night snores, sleeping apnea and a good general condition. At physical examination it was found a non- ulcer and hard - reddish mass occupying the whole nasopharynx.

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A juvenile nasopharyngeal angiofibroma JNA is a growth in the area behind the nose. These growths are benign not cancer , but can damage nerves and bones and block ear and sinus drainage. Almost all JNAs are in teenage boys. Juvenile nasopharyngeal angiofibromas cause symptoms only when they're big enough to keep air from passing through the nose or press on parts of the nose and sinuses. But many think the cells that form the growths are left over from early pregnancy.

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