DIASTAT PRESCRIBING INFORMATION PDF

The names Diastat and Diastat AcuDial refer to the same medicine. The AcuDial system is a specific way of delivering the correct amount of the medicine. Diastat has been approved by the U. While some people may be able to give it to themselves, it is easiest to have someone else do it.

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Send the page " " to a friend, relative, colleague or yourself. We do not record any personal information entered above. As with other benzodiazepines, diazepam should be used with caution in patients with pulmonary disease. Additionally, avoid coadministration with other CNS depressants, especially opioids, unless no other alternatives are available as coadministration significantly increases the risk for respiratory depression, low blood pressure, and death.

Oral diazepam tablets are contraindicated for use in those with severe respiratory insufficiency or sleep apnea syndrome. Diazepam should be used with caution in other pulmonary diseases as well including severe chronic obstructive pulmonary disease COPD , sleep apnea, asthma, or pneumonia because the drug can exacerbate ventilatory failure. Lower doses are recommended in patients with chronic respiratory insufficiency. Oral, parenteral, or rectal long-acting benzodiazepine Used for anxiety, acute alcohol withdrawal, skeletal muscle spasm, and seizure disorders Long-term use not well studied.

Use lower initial adult doses for the debilitated adult patient. In addition, the facility should attempt periodic tapering of the medication or provide documentation of medical necessity in accordance with OBRA guidelines.

Initially, 1 to 2. The dose may be increased as needed and tolerated. For severe anxiety disorders and symptoms of anxiety, 5 to 10 mg IM or IV; repeat in 3 to 4 hours if necessary.

Until it is known how the patient will respond, a dose of 10 mg IV initially, followed by 5 to 10 mg IV every 3 to 4 hours as needed. Doses of 5 to 10 mg IV may be given every hour if required.

Some patients may require massive doses of benzodiazepines during the acute phase of ethanol withdrawal. Intravenous doses of mg over 45 minutes and 2, mg over a period of 4 days have been reported. May repeat in 2 to 4 hours, if needed. Alternately, 1 mg IV every 2 to 5 minutes as needed up to a maximum of 10 mg.

Alternately, 0. Mean total dose: 0. NOTE: It is recommended that rectal diazepam be used to treat no more than 5 episodes per month and no more than 1 episode every 5 days. A second dose may be given 4 to 12 hours after the first dose if needed. Dose may be titrated up to 20 mg IV, depending on response and patient tolerability. Because benzodiazepine withdrawal is more pronounced with shorter-acting agents, diazepam has been proposed as the benzodiazepine of choice for managing withdrawal.

Diazepam-equivalent doses have been established for some other benzodiazepines. Diazepam should be tapered off in increments of 0.

Ten of 11 patients were discharged alive from the hospital. The one patient who died had ingested the largest total dose 15 g of chloroquine. Use is not recommended as a hypnotic due to the long half-life of diazepam, the availability of safer sleep agents, and the increased sensitivity to benzodiazepines e.

Dosage must be individualized. A maximum dose has not been specifically defined by the manufacturer for emergent conditions. Suggested maximum dose: 0. Dosage should be modified depending on clinical response and degree of hepatic impairment, but no quantitative recommendations are available. Dosage should be modified depending on clinical response and degree of renal impairment, but no quantitative recommendations are available; active and inactive diazepam metabolites are excreted by the kidney.

The dose of the oral concentrate solution should be added to 30 ml or more of liquid e. Strict aseptic technique must always be maintained during handling of parenteral products. Diazepam injectable emulsion Dizac contains no antimicrobial preservatives and can support rapid growth of microorganisms.

Following parenteral administration, patients should be kept under observation for a period of 3 to 8 hours or longer, based on the patient's clinical response and rate of recovery.

Replace parenteral therapy with oral therapy as soon as possible. Visually inspect parenteral products for particulate matter and discoloration prior to administration whenever solution and container permit. Diazepam injection solution: No dilution necessary. Dilution may cause precipitation.

Diazepam emulsified injection: For intravenous administration only. Diazepam emulsified injection should be prepared for single patient use only. Diazepam emulsified injection should be prepared for use just prior to initiation of each individual treatment procedure.

The injection emulsion should be drawn into sterile syringes immediately after ampules are opened. The syringe s should be labeled with appropriate information including the date and time the ampule was opened. Administration should commence promptly and be completed within 6 hours after the ampules have been opened. The IV line should be flushed every 6 hours and at the end of treatment procedure to remove residual diazepam emulsified injection. Do not use if there is evidence of separation of the phases of the emulsion.

Intravenous injection: Do not administer rapidly because respiratory depression or hypotension may develop. Monitor heart rate, respiratory rate, and blood pressure during IV use. A large vein should be used to avoid thrombosis. If a large vein is not available, inject into the tubing of a flowing IV solution as close as possible to the vein insertion. Do not add diazepam emulsified injection to infusion sets containing PVC.

Intramuscular injection Diazepam injection solution only : This route is usually not recommended due to slow and erratic absorption. Inject deeply into a large muscle mass. Aspirate prior to injection to avoid injection into a blood vessel. NOTE: Inspect product before preparation and administration.

Small cracks have been noted at the base of the plastic tip of the applicators with resultant leakage of the medication when the plunger is depressed, preventing full dosing and potentially resulting in a sub-optimal therapeutic response.

If a cracked syringe is noted, notify your dispensing pharmacist to inspect the product. Pharmacists should contact Rx Hope at 1——— for replacement product. Diastat AcuDial is available in the following delivery system units: 2. The available doses from the 20 mg delivery system are 10 mg, The available doses from 10 mg delivery system are 5 mg, 7. The 2. It is ready when the "Green Ready Band" in clearly visible.

Hold barrel of the syringe with the cap pointed downward. Grasp cap with the other hand and turn to adjust dose. The prescribed dose should appear in the window.

Grasp and push the locking ring upward to lock both sides of the ring. If the ring is locked at an incorrect dose, call 1——— Administration steps: Put person on their side where they can not fall. Get the medicine and the syringe. To remove protective cover from syringe, push up with thumb and pull.

Ensure that both the cap and seal pin are removed. If an AcuDial syringe is being used, confirm the correct dose by looking at the dose shown on the syringe display window. Also, the green 'ready' band should be visible. Lubricate rectal tip with lubricating jelly. Turn person on side facing you and bend upper leg forward to expose rectum. Separate buttocks to expose rectum. Gently insert syringe tip into rectum rim should be snug against rectal opening and slowly count to 3 while gently pushing the plunger in until it stops.

Slowly count to 3 before removing the syringe from the rectum. Slowly count to 3 while holding the buttocks together to prevent leakage. Keep person on the side facing you, note time given and continue to observe. If an AcuDial syringe was used, pull the plunger out and then replace and push in to expel any remaining drug into the sink or toilet. Generic: - Store at controlled room temperature between 68 and 77 degrees F Diastat: - Store at 77 degrees F; excursions permitted to degrees F Dizac: - Discard product if it contains particulate matter, is cloudy, or discolored - Protect from light - Store at controlled room temperature between 68 and 77 degrees F Valium: - Protect from light - Store at controlled room temperature between 68 and 77 degrees F.

Diazepam is contraindicated in any patient with a known or suspected hypersensitivity to diazepam or with sensitivity to any component of the formulation. Patients with a benzodiazepine hypersensitivity to other benzodiazepines may experience a cross-sensitivity to diazepam. Intravenous diazepam should be injected slowly to reduce the possibility of local reactions; avoid intraarterial administration or extravasation.

Do not dilute diazepam injection with other solutions or drugs. If direct IV access is not feasible, inject slowly via infusion tubing as close as possible to the vein insertion. Although diazepam is occasionally beneficial for patients with major depression, the drug should be administered cautiously to patients with suicidal ideation. Large quantities of benzodiazepines should not be prescribed for patients with known suicidal ideation or a history of suicide attempt. In addition, worsening of depressive symptoms may occur during diazepam administration.

Benzodiazepines should be used cautiously in patients with bipolar disorder because mania and hypomania have been reported in conjunction with the use of benzodiazepines in depressive disorders. The manufacturer states that diazepam has no use in psychosis and should not be used in lieu of appropriate therapy.

Diazepam can cause physical and psychological dependence, and should be used with extreme caution in patients with known, suspected or a history of substance abuse.

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