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Refer to the Help section for more detailed instructions. Select one Select one.. Advanced Search Small Search Button. Back to Previous Page. File Format:. Published Date:. Alternative Title:. Personal Author:. Shea, Patrick R. Group A Streptococcus GAS is a human-adapted pathogen that causes a variety of diseases, including pharyngitis and invasive infections.
GAS strains are categorized by variation in the nucleotide sequence of the gene emm that encodes the M protein. To identify the emm types of GAS strains causing pharyngitis in Ontario, Canada, we sequenced the hypervariable region of the emm gene in 4, pharyngeal GAS isolates collected during The most prevalent emm types varied little from year to year. In contrast, fine-scale geographic analysis identified inter-site variability in the most common emm types.
Additionally, we observed fluctuations in yearly frequency of emm3 strains from pharyngitis patients that coincided with peaks of emm3 invasive infections. We also discovered a striking increase in frequency of emm89 strains among isolates from patients with pharyngitis and invasive disease.
These findings about the epidemiology of GAS are potentially useful for vaccine research. Document Type:. Journal Article. Collection s :. Emerging Infectious Diseases. Main Document Checksum:. Supporting Files:. Related Documents:. You May Also Like:. Jun Emerg Infect Dis.
During , a scarlet fever epidemic characterized by peak monthly incidence rates 2. During t File Type:. Moses, Allon E. Corporate Authors:. Israeli Group. Apr We conducted a prospective, nationwide, population-based study of invasive group A streptococcal infections in Israel. We identified patients median age 27 years; range File Type:. Oct International circumpolar surveillance interlaboratory quality control program for emm typing of Streptococcus pyogenes, — May 12 Diagn Microbiol Infect Dis.
In , an interlaboratory quality control QC program for emm typing group A streptococci GAS was incorporated into existing international circumpolar surveillance QC programs.
From - , 35 GAS isolates were distributed to three laborato Outbreak of invasive infections from subtype emm Mar 19 Clin Infect Dis. We characterized the outbreak and implemented a mass antibiotic inter
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